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COMPOSITION:
Mupirocin IPĀ 2% w/w
In a non-greasy baseĀ q.s
DESCRIPTION: Mupirocin ointment, 2% contains the RNA synthetase inhibitor antibacterial, mupirocin.
CATEGORY: Antimicrobial
CLINICAL PHARMACOLOGY:
Pharmacodynamic properties
Mupirocin is an RNA synthetase inhibitor antibacterial. Mupirocin is a novel antibiotic produced through fermentation by Pseudomonas fluorescens. Mupirocin inhibits isoleucyl transfer-RNA synthetase, thereby arresting bacterial protein synthesis. Mupirocin has bacteriostatic properties at minimum inhibitory concentrations and bactericidal properties at the higher concentrations reached when applied locally
Mupirocin has been shown to be active against strains of S. aureus and Streptococcus pyogenes (S pyogenes), both in vitro and in clinical studies. Mupirocin is active against most strains ofĀ Staphylococcus epidermidisĀ (S. epidermidis) and Staphylococcus saprophyticus.Ā Corynebacterium spp. and Micrococcus spp. are inherently resistant to mupirocin.
Pharmacokinetic properties
After topical application of Mupirocin Ointment, mupirocin is only very minimally absorbed systemically and that which is absorbed is rapidly metabolised to the antimicrobially inactive metabolite, monic acid.
Penetration of mupirocin into the deeper epidermal and dermal layers of the skin is enhanced in traumatised skin and under occlusive dressings.
INDICATIONS:
Mupirocin Ointment IP 2 % w/w is indicated for the topical treatment of canine bacterial infections of the skin, including superficial pyoderma, caused by susceptible strains of the following organisms:
Staphylococcus aureus and Staphylococcus intermedius.
DOSAGE AND ADMINISTRATION:
Prior to treatment the lesion should be cleansed
Mupirocin Ointment IP 2 % w/w should be applied to the affected area twice a day.
Apply a sufficient amount of ointment to completely cover the affected area.
The maximum duration of treatment should not exceed 30 days.
It should be used as directed by the Veterinarian.
CONTRAINDICATIONS:
This drug is contraindicated in animals with a history of sensitivity reactions to any of its components.
WARNINGS AND PRECAUTIONS:
Mupirocin Ointment IP 2% w/w is not for ophthalmic use.
Use this medication only as directed by the veterinarian. It is for external use only. Avoid contact with the eyes. If mupirocin gets in or near the eyes, rinse thoroughly with water. If no improvement is seen in 3 to 5 days, contact the veterinary doctor. The treated area may be covered by gauze dressing if desired. Report to the veterinary doctor, if any signs of local adverse reactions.
PREGNANCY AND LACTATION:
Safety of use in pregnant or breeding animals has not been determined.
ADVERSE DRUG REACTIONS:
No adverse reactions have been reported with this product. If a skin reaction such as irritation occurs, treatment should be discontinued and appropriate therapy instituted
OVERDOSAGE:
An overdose of Mupirocin Ointment IP 2% w/w is unlikely to occur. If an overdose is suspected, seek emergency veterinary medical treatment.
Indications:
- Skin infection specifically by virulent MRS strains
- Post-operative care
- Burns and wound
Application:
Twice a day
Presentation:
15g & 7.5g Tube
