Otomite 4 * 1 Ear drop 10 ML

Composition (per 1 ml):

• Thiabendazole – 1 mg

• Clotrimazole – 10 mg

• Florfenicol – 2.5 mg

• Betamethasone (as dipropionate) – 1 mg

• Excipients: Dimethyl sulfoxide, ethanol, polyethylene glycol, propylene glycol

Pharmacological Properties:

OTOMITE is a multifunctional otic preparation with antiparasitic, antifungal, antimicrobial, anti-inflammatory, and antipruritic effects. Its efficacy is derived from the synergistic actions of its active components:

Thiabendazole:

• Antiparasitic and antifungal agent.

• Effective against bacteria and ear mites.

• Indicated for acute and chronic otitis externa.

• Treats dermatomycoses caused by Microsporum and Trichophyton in dogs and cats.

Clotrimazole:

• An imidazole derivative with broad antifungal activity.

• Disrupts fungal cell membrane synthesis by inhibiting ergosterol production, leading to cell lysis.

• Active against:

  • Dermatophytes and yeasts (Candida, Torulopsis glabrata, Rhodotorula)

  • Fungi causing Pityriasis versicolor and erythrasma

  • Gram-positive and gram-negative bacteria (Staphylococci, Streptococci, Bacteroides, Gardnerella vaginalis)

  • Other organisms: Trichomonas vaginalis, Malassezia furfur, Corynebacterium minutissimum

Florfenicol:

• A broad-spectrum bacteriostatic antibiotic derived from thiamphenicol.

• Inhibits bacterial protein synthesis by binding to the 70S ribosomal subunit and inhibiting peptidyl transferase.

• Effective against:

  • Gram-positive and gram-negative bacteria: Streptococcus spp., Staphylococcus spp., Pasteurella spp., Salmonella spp., Proteus spp., Pseudomonas spp., Haemophilus spp.

  • Anaerobes: Fusobacterium necrophorum, Bacteroides melaninogenicus

  • Atypical pathogens: Mycoplasma spp., Rickettsia spp., Chlamydia spp.

Betamethasone (as dipropionate):

• A potent corticosteroid with anti-inflammatory and antipruritic properties.

• Reduces inflammation and discomfort in the ear canal, aiding in faster recovery.

Here is the completed and professionally formatted product profile for OTOMITE, suitable for brochures, product datasheets, or a veterinary product catalog:

OTOMITE – Otic Solution for Dogs, Cats, and Decorative Rabbits

Composition (per 1 ml):

• Thiabendazole – 1 mg

• Clotrimazole – 10 mg

• Florfenicol – 2.5 mg

• Betamethasone (as dipropionate) – 1 mg

• Excipients: Dimethyl sulfoxide, ethanol, polyethylene glycol, propylene glycol

Pharmacological Properties:

OTOMITE is an advanced otic formulation offering antiparasitic, antifungal, antimicrobial, anti-inflammatory, antipruritic, and anti-allergic actions. Its therapeutic effect is based on the synergistic combination of its active ingredients:

• Thiabendazole: Effective against mites, fungi (Microsporum, Trichophyton), and bacteria; used in acute/chronic otitis externa.

• Clotrimazole: An imidazole antifungal that disrupts fungal cell membranes and exhibits additional antibacterial and antiprotozoal properties.

• Florfenicol: A broad-spectrum bacteriostatic antibiotic that inhibits bacterial protein synthesis.

• Betamethasone (as dipropionate): A synthetic corticosteroid with potent anti-inflammatory, antipruritic, anti-allergic, and anti-proliferative effects.

Target Animals:

• Dogs

• Cats

• Decorative rabbits

Indications:

OTOMITE is indicated for the treatment of otitis in small companion animals (dogs, cats, rabbits), including:

• Otitis of varied etiologies

• Otitis caused by ectoparasites

• Otitis complicated by bacterial or fungal infections

Route of Administration & Dosage:

Otic (ear) administration only.
Before application, clean the external ears and ear canal to remove wax, exudate, and debris.

Instill twice daily in each ear for 5–10 consecutive days, depending on clinical severity.

Table 1 – Dosage Guide:

Note: After instillation, fold the ear lengthwise and massage the base gently to ensure proper distribution.

Contraindications:

• Do not use in:

  • Sick or emaciated animals

  • Lactating animals

  • Puppies, kittens, or rabbits under 10 weeks of age

  • Animals sensitive to any ingredient in the product

• Do not use Ivermectin in sensitive dog breeds (e.g., Collies, Shelties, Bobtails)

Precautions:

• Prevent the animal from licking the treated area for at least 10 minutes

• Avoid contact with mucous membranes

• Wash hands thoroughly with warm, soapy water after application

Shelf Life:

• 36 months from the date of manufacture

Storage Conditions:

• Store in a dry, dark place

• Keep out of reach of children

• Maintain temperature between 5°C and 25°C