Metonin Inj 10 mg 20 ml

Active Ingredient:

• Maropitant Citrate – 10 mg/ml

Presentation:

• 20 ml vial

Shelf Life:

• 36 months (Use within 90 days of first vial puncture)

Storage:

• Before opening: Store at controlled room temperature (15°C–30°C / 59°F–86°F).

• After first puncture: Store at 2°C–8°C (36°F–46°F) and use within 90 days.

Indications:

Dogs:

• Treatment and prevention of vomiting (including chemotherapy- or motion sickness-induced).

• Prevention of vomiting (except foreign body obstruction cases).

• Used with supportive therapy for managing vomiting.

Cats:

• Prevention of vomiting and reduction of nausea.

• Treatment of vomiting in combination with supportive measures.

Mechanism of Action:

Maropitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P in the central nervous system and gastrointestinal tract, effectively preventing vomiting.

Dosage & Administration:

• Species: Dogs (≥8 weeks) and Cats (≥16 weeks)

• Route: Subcutaneous injection

• Dosage: 1 mg/kg (0.1 ml/kg) once daily

• Duration: Up to 5 consecutive days

Additional Notes:

• Administer at least 1 hour before situations likely to induce vomiting (e.g., travel, chemotherapy).

• May be given the day before chemotherapy for prevention.

• Can be combined with other treatments as needed.

Side Effects:

Common:

• Pain or swelling at the injection site

• Vomiting or hypersalivation at higher doses

Less Common/Rare:

• Lethargy, decreased appetite

• Diarrhea

• Allergic reactions

• Incoordination, convulsions

• In cats: panting, muscle tremors, abnormal posture (e.g., inability to rise)

Note:
Effects usually resolve within 24 hours but may last longer in pets with liver or kidney disease.

Drug Interactions:

• Use cautiously with:

  • Chloramphenicol, Phenobarbital, Erythromycin, Ketoconazole, Itraconazole, NSAIDs

• Maropitant is highly protein-bound; caution when combined with other protein-bound drugs (e.g., anticonvulsants, behavioral medications).

Precautions:

• Not evaluated in breeding animals or in cases of GI obstruction or toxin ingestion.

• Use cautiously in pets with hepatic impairment (metabolized by CYP enzymes).

• Monitor closely when used with CYP inhibitors or other highly protein-bound drugs.

Important Warnings:

• For Veterinary Use Only

• Not for Human Use

• Keep Out of Reach of Children