Doxypet Tab

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Description

 

COMPOSITION:

Each film coated tablet contains

Doxycycline Hydrochloride IP    Eq. to Doxycycline 100 mg

Lactic Acid Bacillus 100 million spores

Excipients Q.S.

Colour: Quinoline Yellow

DESCRIPTION

DOXYPET 100 tablet contains doxycycline and lactic acid bacillus. Doxycycline is an antibacterial drug synthetically derived from oxytetracycline. Doxycycline has a high degree of lipid solubility and a low affinity for calcium binding. Lactic acid bacillus is Gram positive, spore forming and lactic acid producing bacillus.

CLINICAL PHARMACOLOGY

Pharmacodynamics

Doxycycline

It is active against a large number of Gram positive and Gram negative pathogens including strains resistant to first generation tetracyclines.

bacteriostatic; it inhibits the bacterial protein synthesis by blocking binding of transfer RNA to the messenger RNA-ribosome complex.

Lactic Acid Bacillus

Lactic acid bacilli are helpful bacteria, occurs naturally in intestine and constitute major part of the intestinal microflora.

Lactic acid bacillus is presumed to be result of improving gastrointestinal ecology by replenishing the quantity of desirable obligate microorganisms and antagonizing pathogenic microbes.

Pharmacokinetics

Doxycycline

Doxycycline is completely absorbed from the upper part of the gastrointestinal tract after oral administration.

Doxycycline is more lipophilic than most tetracyclines.

Thus, it has better bioavailability (as compared to most tetracyclines; 90-100%) and is rapidly absorbed (80-90% of oral dose within an hour) with a longer serum half-life (19-20 hours).

In spite of a high protein binding rate, the volume of distribution of doxycycline is high demonstrating that doxycycline is broadly distributed in organs and tissues.

Doxycycline is metabolized by the liver and is mainly excreted as unchanged drug and eliminated in feces and urine,

Lactic Acid Bacillus

After oral administration, lactic acid bacillus passes through the stomach in its spore form and upon arrival in the duodenum, it germinates and multiplies rapidly. The average duration of the time between oral dosage and germinations is four hours. After germination, lactic acid bacilli are metabolically active in the intestine and resulting in production of lactic acid. lactic acid bacillus is considered as a semi resident indicating that it takes up only a temporary residence in intestine

Spore of lactic acid bacillus are excreted slowly via the faeces for appropriately seven days after discontinuation of administration.

INDICATIONS

For the treatment of infections caused by bacteria (including Spirochete and Rickettsia) and hemoprotozoa

For the treatment of respiratory tract infections in dogs. including rhinitis, tonsillitis and bronchopneumonia

Treatment of arthropod-borne Ehrlichia canis infection in dogs

DOSAGE AND ADMINISTRATION

Recommended dosage for dog is 10 mg/kg body weight (One tablet for 10 kg) once a day for 7 to 28 days and may vary according to the severity and type of infections

CONTRAINDICATIONS

Do not use in pregnant or lactating female dogs

Do not use in known cases of hypersensitivity to the active ingredient.

WARNINGS AND PRECAUTIONS

Special precautions for use in young dogs Do not exceed the recommended dosage.

Tablets should be administered at feeding time.

ADVERSE REACTIONS

Photodermatitis may occur following tetracycline therapy after exposure to intense sunlight or ultraviolet light

Use of tetracycline during the period of tooth development may lead to tooth discoloration. Doxycycline, because of its lower affinity for calcium, carries a lower risk than other tetracyclines.

Vomiting, esophagitis and esophageal ulcerations have been reported as side effects following doxycycline therapy. To alleviate these effects, the drug can be given with food without clinically significant reductions in drug absorption.

In cats, oral doxycycline has been implicated in causing esophageal strictures. If using oral tablets, be sure that

"pilling" is followed by at least 6 mL of water. Do not give

DRUG INTERACTIONS

Cross resistance to other tetracyclines can occur

Doxycycline should not be used concurrently with other antibiotics especially bactericidal drugs such as the B-lactams.

The hail-lite of doxycycline is reduced by concurrent administration of barbiturates or phenytoin.

Simultaneous administration of oral absorbents, iron preparations and antacids should be avoided as they reduce doxycycline availability.

Dosage:
10 mg/kg bw once daily

Vector Borne Disease:

- Ehrlichiosis
- Babesiosis
- Leptospirosis
- Lyme Disease

Treatment Duration:

- Upto 28 days
- Upto 14 days
- Upto 21 days
- Upto 28 days

Presentation:
1 X 10 Tablets

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