COMPOSITION
Each 5 ml reconstituted suspension contains:
Cephalexin IP eq. to
Anhydrous Cephalexin 250 mg
Excipient Q.S.
Colour: Erythrosine
DESCRIPTION:
CEPHAVET is oral suspension containing 250 mg of cephalexin. Cephalexin is a cephalosporin, p-lactam, broad spectrum antibiotic. The full chemical name for cephalexin is 7-(D-a-amino-a-phenylacetamido) -3-methyl-3-cephem-4-carboxylic acid monohydrate.
CLINICAL PHARMACOLOGY: Cephalexin belongs to the cephalosporin family of bactericidal antibiotics. Like other p-lactam antimicrobials, cephalexin exerts its inhibitory effect by interfering with bacterial cell wall synthesis. This interference is primarily due to its covalent binding to the penicillin-binding proteins (PBPs) (i.e., transpeptidase and carboxypeptidase), which are essential for synthesis of the bacterial wall.
Cephalexin is readily and almost completely absorbed following oral administration (90% absolute bioavailability). Blood concentrations are proportional to dose within the range of at least 15 to 45 mg/kg. Binding to canine plasma proteins is low, ranging from 9, to 13% cephalexin
concentrations of 0.5 to 100 ug/mL.
Food reduces the peak cephalexin concentrations but has negligible effect on the extent of absorption.
MICROBIOLOGY: Cephalexin has greater activity against Staphylococci and gram-negative bacteria. It has excellent activity against Staphylococcus spp, Streptococcus spp, E coli, Proteus and Klebsiella.
INDICATIONS: For the treatment primary or secondary bacterial skin infections. Also for the treatment of the urinary tract, respiratory tract, bones and joints infections
DOSAGE AND ADMINISTRATION: For Dogs, recommended dose is 15 mg/kg of body weight twice or 30 mg/kg of body weight once a day. For cats, recommended dose is 20 mg/kg once a day. Appropriate culture and susceptibility tests should be performed before treatment to determine the causative organism and its susceptibility to cephalexin. Antimicrobial therapy should be adjusted according to the tests. If acceptable response to treatment is not observed, then the diagnosis should be re-evaluated and appropriate alternative therapy considered
Reconstitution Instructions - Oral Suspension
Slowly add boiled and cooled water up to the ring mark on the bottle .Shake vigorously. Adjust the volume upto the ring mark by adding more water, if necessary. This makes 60 ml suspension. Each 5 mL of suspension will contain 250 mg of cephalexin.
CEPHAVET oral suspension can be given with dosing syringe.
Directions for Administration:
- Shake well before use.
- Unscrew the bottle.
- Insert the dosing syringe to the bottle.
- Withdraw required dose as per body weight or as directed by Registered veterinary practitioner.
CONTRAINDICATIONS: CEPHAVET oral suspension is contraindicated in dogs and cats with a known allergy to cephalexin or to the p-lactam (any of the penicillins or cephalosporins) group of antibiotics.
WARNINGS: Antimicrobials, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. Sensitized individuals handling such antimicrobials, including cephalexin, should avoid contact of the product with the skin and mucous membranes in order to minimize the risk of allergic reactions. Keep this drug out of the reach of children.
VETERINARY
FOR USE IN DOGS AND CATS NOT FOR HUMAN USE
FOR TREATMENT OF DOGS & CATS ONLY
PRECAUTIONS: The safe use of CEPHAVET oral suspension in dogs and cats intended for breeding and use in pregnancy or lactation not been evaluated.
ADVERSE REACTIONS: In the event of an allergic reaction such as shortness of breath, rash, hives, vomiting, diarrhea, mucous or blood in the stool, swelling of the lips, tongue, or face, and unusual bleeding or bruising.
PRESENTATION: 60ml Bottle with dosing syringe.
STORAGE: Store in a cool and dry place below 25°C.
Protect from direct light.
Any unused portion of the reconstituted suspension must be discarded after 7 days.
