Cephavet (Cephalexin)

CEPHAVET 300

COMPOSITION:

Each uncoated tablet contains:

Cephalexin IP as Monohydrate eq. to Anhydrous   Cephalexin 300 mg

Indications:
- Skin infections
- Urinary Tract Infections

CLINICAL PHARMACOLOGY:

Cephalexin belongs to the cephalosporin family of bactericidal antibiotics Like other p-lactam antimicrobials, cephalexin exerts its inhibitory effect by interfering with bacterial cell wall synthesis. This interference is primarily due to its covalent binding to the penicillin-binding proteins (PBPs) (i.e., transpeptidase and carboxypeptidase), which are essential for synthesis of the bacterial wall.

Cephalexin is readily and almost completely absorbed following oral administration (90% absolute bioavailability). Blood concentrations are proportional to dose within the range of at least 15 to 45 mg/kg. Binding to canine plasma proteins is low, ranging from 9 to 13% cephalexin concentrations of 0.5 to 100 pg/mL.

the extent of absorption.

MICROBIOLOGY:

Cephalexin has greater activity against Staphylococci and gram-negative bacteria. It has excellent activity against Staphylococcus spp, Streptococcus spp, E coli, Proteus and Klebsiella.

INDICATIONS:

For the treatment bacterial skin infections and urinary tract infection in dogs and cats caused by susceptible strains of bacteria.

Also for the treatment of the respiratory tract, bones and joints infections.

DOSAGE AND ADMINISTRATION:

The recommended dose is 15 mg/kg of body weight twice for Urinary Tract Infection and 30 mg/kg of body weight once a day for Skin infection (One tablet for 10 kg body weight once or 1/2 tablet for 10 kg body weight twice a day).

*Appropriate culture and susceptibility tests should be performed before treatment to determine the causative organism and its susceptibility to cephalexin. Antimicrobial therapy should be adjusted according to the tests, Il acceptable response to treatment is not observed, then the diagnosis should be re-evaluated and appropriate alternative therapy considered.

CONTRAINDICATIONS:

CEPHAVET tablets are contraindicated in dogs & cats with a known allergy to cephalexin or to the p-lactam (any of the penicillins or cephalosporins) group of antibiotics

WARNINGS:

Antimicrobials, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. Sensitized individuals handling such antimicrobials, including cephalexin, should avold contact of the product with the skin and mucous membranes in order to minimize the risk of allergic reactions. Keep this drug out of the reach of children.

FOR VETERINARY USE ONLY.

NOT FOR HUMAN USE

FOR TREATMENT OF DOGS AND CATS ONLY.

PRECAUTIONS:

The safe use of CEPHAVET tablets in dogs & cats intended for breeding and in pregnant or lactating bitches has not been evaluated.

ADVERSE REACTIONS:

vomiting, diarrhea, mucous or blood in the stool, swelling of the lips, tongue, or face, and unusual bleeding or bruising.

STORAGE:

Store protected from light & moisture, at a temperature not exceeding 30° C.

Presentation:
1 x 10 Tablets 60ml Bottle